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Classes of CPPs

   A reasonable classification of cell penetrating peptides can be given in terms of general aspects of the amino acids content and sequence:

 

 

Authors:

Keywords:

Hydrophilic

These are peptides composed mainly by hydrophilic amino acids usually rich in arginine and lysine amino acids. i.e. penetratin, tat.

Authors:

Keywords: , AIDS Vaccines/*therapeutic use, Amino Acid Sequence, Animals, Autoimmune Diseases/*prevention & control, Base Sequence, Cholesterol/chemistry

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Amphiphilic

Amphipathic peptides, usually rich in lysine amino acids. These two characteristics are shared by many antimicrobial peptides. i. e. MAP, and transportan

 

Authors: Salamon (Z), Zhou (S H)

Keywords: AIDS Vaccines/*therapeutic use, *Circular Dichroism, Chromatography, Ion Exchange/methods

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Periodic sequence

Peptides which contain an amino acid sequence motif replicated several times. i. e. pVec, and pep-1.

 

 

Authors: Eiriksdottir (E), Choi (S Y)

Keywords: Insulin/secretion

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A short list of some cpps

Cell Penetrating peptide

Hydrophilic

Penetratin or Antenapedia PTD RQIKWFQNRRMKWKK

TAT YGRKKRRQRRR

SynB1 RGGRLSYSRRRFSTSTGR

SynB3 RRLSYSRRRF

PTD-4 PIRRRKKLRRLK

PTD-5 RRQRRTSKLMKR

FHV Coat-(35-49) RRRRNRTRRNRRRVR

BMV Gag-(7-25) KMTRAQRRAAARRNRWTAR

HTLV-II Rex-(4-16) TRRQRTRRARRNR

D-Tat GRKKRRQRRRPPQ

R9-Tat GRRRRRRRRRPPQ

Amphiphilic

Transportan GWTLNSAGYLLGKINLKALAALAKKIL chimera

MAP KLALKLALKLALALKLA

SBP MGLGLHLLVLAAALQGAWSQPKKKRKV

FBP GALFLGWLGAAGSTMGAWSQPKKKRKV

MPG ac-GALFLGFLGAAGSTMGAWSQPKKKRKV-cya

MPG^(ΔNLS)  ac- GALFLGFLGAAGSTMGAWSQPKSKRKV-cya

Pep-1    ac-KETWWETWWTEWSQPKKKRKV-cya

Pep-2    ac-KETWFETWFTEWSQPKKKRKV-cya

Periodic sequences

Polyarginines RxN (4<N<17) chimera

Polylysines KxN (4<N<17) chimera

(RAca)6R

(RAbu)6R

(RG)6R

(RM)6R

(RT)6R

(RS)6R

R10

(RA)6R

R7

 

 

Authors: Ezhevsky (S A), Zhou (S H), Ezhevsky (S A), Zhou (S H)

Keywords: , Carrier Proteins/*chemistry

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