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Design of CPPs

The design of CPPs can be divided in two major approaches:

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Functional method

It can be assumed a reasonable mechanism of entry and then look for changes on the structure of the peptide that will enhance the hypothetical mechanism.  Several experiments have shown that a crucial step for the peptide uptake is the initial binding to the membrane. Therefore, the design of several peptides is based on the optimization of the interaction between the membrane and the peptides

Authors: Schluesener (H J)

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Homological method

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Massive screening

This can be done using for example phage display technology building first a library of peptides that bind to the membrane and then assess functionality as intracellular carriers.

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