Reference ID: 18093956

PMID

Title

Subtitle

Short title

Publication

Authors:

If the author doesn't exist, please add him/her.

Add Author | Close

If the keyword doesn't exist, please add it.

Keywords:

Add Keyword | Close

Author Address:

Publication:

Publication month: January February March April May June July August September October November December Publication Year:

Volume number Issue number

Start and end pages
If the article has page numbers, enter either arabic or roman numerals
Start page End page

Abstract
The human immunodeficiency virus-1 (HIV-1) Tat peptide is taken up by a variety of cells in vitro and in vivo (Anderson et al.: Biochem Biophys Res Commun 194:876-884, 1993; Fawell et al.: Proc Natl Acad Sci USA 91:664-668, 1994; Chen et al.: Anal Biochem 227:168-175, 1995). We have used Tat37-72, the fragment containing a domain binding to alpha v beta 5 integrin (Vogel et al.: J Cell Biol 121:461-468, 1993), to deliver a fusion protein of three pathogenic rat T-cell epitopes, MBP68-84, P2,53-78, and IRBP1169-1191 systemically and via mucoepithelial surfaces. This recombinant polyvalent vaccine peptide, toolbox101, is-depending on the route of administration-specifically immunosuppressive and can be used to vaccinate against experimental autoimmune encephalomyelitis, neuritis, and uveoretinitis and is, in addition, of therapeutic value.

Notes

Url

DOI

ISBN

Repository

Add a preprint

Peer Reviewed

Peptides

Names, semicolon separated

(i.e. Penetratin; Tat; MAP; etc)

Peptide Sequences, semicolon separated

(i.e. Arg-Lys-Lys-Arg; Sar-Lys-Lys-Sar; etc)

Security Code

Login

Username

Password

Forgot your password?

Do you still don't have an account?

Register